Presenilins, Processing of β-Amyloid Precursor Protein, and Notch Signaling
نویسندگان
چکیده
منابع مشابه
Presenilins, Processing of β-Amyloid Precursor Protein, and Notch Signaling
specific functions. Notch itself is a single-pass transTwo seemingly unrelated avenues of research, Alzheimembrane receptor with large extracellular and intracelmer’s disease and developmental cell fate specification, lular domains (Figure 1A). During receptor maturation, have intersected at the presenilin and Notch genes. ReNotch is cleaved in its extracellular domain by furin or a cent report...
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The amyloid precursor protein (APP) must fulfill important roles based on its sequence conservation from fly to human. Although multiple functions for APP have been proposed, the best-known role for this protein is as the precursor of Abeta peptide, a neurotoxic 39-43-amino acid peptide crucial to the pathogenesis of Alzheimer's disease. To investigate additional roles for APP with an eye towar...
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In addition to its documented role in the proteolytic processing of Notch-1 and the beta-amyloid precursor protein, presenilin 1 (PS1) associates with beta-catenin. In this study, we show that this interaction plays a critical role in regulating beta-catenin/T Cell Factor/Lymphoid Enhancer Factor-1 (LEF) signaling. PS1 deficiency results in accumulation of cytosolic beta-catenin, leading to a b...
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ژورنال
عنوان ژورنال: Neuron
سال: 1999
ISSN: 0896-6273
DOI: 10.1016/s0896-6273(00)80771-0